Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

Ubiquitin modification is mediated by a large family of specificity determining ubiquitin E3 ligases. To facilitate ubiquitin transfer, RING E3 ligases bind both substrate and a ubiquitin E2 conjugating enzyme linked to ubiquitin via a thioester bond, but the mechanism of transfer has remained elusi...

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Detalles Bibliográficos
Autores principales: Plechanovová, Anna, Jaffray, Ellis, Tatham, Michael H., Naismith, James H., Hay, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442243/
https://www.ncbi.nlm.nih.gov/pubmed/22842904
http://dx.doi.org/10.1038/nature11376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442243/
https://www.ncbi.nlm.nih.gov/pubmed/22842904
http://dx.doi.org/10.1038/nature11376

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