Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells

As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors lacking wt p53, this phenomenon can be exploited to protect normal cells from chemotherapy because all normal cells have wt p53. Also,...

Descripción completa

Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442293/
https://www.ncbi.nlm.nih.gov/pubmed/22802145
_version_ 1782243448865161216
author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors lacking wt p53, this phenomenon can be exploited to protect normal cells from chemotherapy because all normal cells have wt p53. Also, several therapeutic paradigms can be reassessed, including the role of cellular senescence in cancer therapy.
format Online
Article
Text
id pubmed-3442293
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-34422932012-09-14 Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Blagosklonny, Mikhail V. Oncotarget Research Perspectives As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors lacking wt p53, this phenomenon can be exploited to protect normal cells from chemotherapy because all normal cells have wt p53. Also, several therapeutic paradigms can be reassessed, including the role of cellular senescence in cancer therapy. Impact Journals LLC 2012-07-13 /pmc/articles/PMC3442293/ /pubmed/22802145 Text en Copyright: © 2012 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Blagosklonny, Mikhail V.
Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
title Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
title_full Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
title_fullStr Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
title_full_unstemmed Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
title_short Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
title_sort wt p53 impairs response to chemotherapy: make lemonade to spare normal cells
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442293/
https://www.ncbi.nlm.nih.gov/pubmed/22802145
work_keys_str_mv AT blagosklonnymikhailv wtp53impairsresponsetochemotherapymakelemonadetosparenormalcells

Ejemplares similares