Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

Using specific inhibitors, kinase-negative mutants, and small interfering RNA against protein kinase Cα (PKCα) or PKCβI, we find that PKCβI positively regulates degranulation in rat basophilic leukemia–2H3 cells, whereas PKCα negatively regulates degranulation. Mass spectrometric and mutagenic analy...

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Detalles Bibliográficos
Autores principales: Sakuma, Megumi, Shirai, Yasuhito, Yoshino, Ken-ichi, Kuramasu, Maho, Nakamura, Tomofumi, Yanagita, Toshihiko, Mizuno, Kensaku, Hide, Izumi, Nakata, Yoshihiro, Saito, Naoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442417/
https://www.ncbi.nlm.nih.gov/pubmed/22855535
http://dx.doi.org/10.1091/mbc.E12-01-0053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442417/
https://www.ncbi.nlm.nih.gov/pubmed/22855535
http://dx.doi.org/10.1091/mbc.E12-01-0053

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