A Conformational Switch in a Partially Unwound Helix Selectively Determines the Pathway for Substrate Release from the Carnitine/γ-Butyrobetaine Antiporter CaiT

CaiT is a homotrimeric antiporter that exchanges l-carnitine (CRN) with γ-butyrobetaine (GBB) across the bacterial membrane. Three structures have been resolved to date for CaiT, all in the inward-facing state: CRN-bound (with four CRNs per subunit), GBB-bound (two GBBs per subunit), and apo. One of...

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Detalles Bibliográficos
Autores principales: Zomot, Elia, Bahar, Ivet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442516/
https://www.ncbi.nlm.nih.gov/pubmed/22843728
http://dx.doi.org/10.1074/jbc.M112.397364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442516/
https://www.ncbi.nlm.nih.gov/pubmed/22843728
http://dx.doi.org/10.1074/jbc.M112.397364

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