E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry

Resistance to anti-neoplastic agents is the major cause of therapy failure, leading to disease recurrence and metastasis. E2F1 is a strong inducer of apoptosis in response to DNA damage through its capacity to activate p53/p73 death pathways. Recent evidence, however, showed that E2F1, which is aber...

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Detalles Bibliográficos
Autores principales: Alla, Vijay, Kowtharapu, Bhavani S., Engelmann, David, Emmrich, Stephan, Schmitz, Ulf, Steder, Marc, Pützer, Brigitte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442917/
https://www.ncbi.nlm.nih.gov/pubmed/22871739
http://dx.doi.org/10.4161/cc.21476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442917/
https://www.ncbi.nlm.nih.gov/pubmed/22871739
http://dx.doi.org/10.4161/cc.21476

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