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Protein Trans-Splicing of an Atypical Split Intein Showing Structural Flexibility and Cross-Reactivity

Inteins catalyze a protein splicing reaction to excise the intein from a precursor protein and join the flanking sequences (exteins) with a peptide bond. In a split intein, the intein fragments (I(N) and I(C)) can reassemble non-covalently to catalyze a trans-splicing reaction that joins the exteins...

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Detalles Bibliográficos
Autores principales: Song, Huiling, Meng, Qing, Liu, Xiang-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443213/
https://www.ncbi.nlm.nih.gov/pubmed/23024818
http://dx.doi.org/10.1371/journal.pone.0045355