High Glucose Predisposes Gene Expression and ERK Phosphorylation to Apoptosis and Impaired Glucose-Stimulated Insulin Secretion via the Cytoskeleton

Chronic high glucose (HG) inflicts glucotoxicity on vulnerable cell types such as pancreatic β cells and contributes to insulin resistance and impaired insulin secretion in diabetic patients. To identify HG-induced cellular aberrations that are candidate mediators of glucotoxicity in pancreatic β ce...

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Detalles Bibliográficos
Autores principales: Yeo, Ronne Wee Yeh, Yang, Kaiyuan, Li, GuoDong, Lim, Sai Kiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443235/
https://www.ncbi.nlm.nih.gov/pubmed/23024780
http://dx.doi.org/10.1371/journal.pone.0044988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443235/
https://www.ncbi.nlm.nih.gov/pubmed/23024780
http://dx.doi.org/10.1371/journal.pone.0044988

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