TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN

The oncogenic MUC1-C subunit is aberrantly overexpressed in most human breast cancers by mechanisms that are not well understood. The present studies demonstrate that stimulation of non-malignant MCF-10A cells with epidermal growth factor (EGF) or heregulin (HRG) results in marked upregulation of MU...

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Detalles Bibliográficos
Autores principales: Jin, Caining, Rajabi, Hasan, Rodrigo, Christina M., Porco, John A., Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443512/
https://www.ncbi.nlm.nih.gov/pubmed/22689062
http://dx.doi.org/10.1038/onc.2012.236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443512/
https://www.ncbi.nlm.nih.gov/pubmed/22689062
http://dx.doi.org/10.1038/onc.2012.236

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