Anti-angiogenic therapy increases intratumoral adenovirus distribution by inducing collagen degradation

Conditionally replicating adenoviruses (CRAd) are a promising class of gene therapy agents that can overcome already known glioblastoma (GBM) resistance mechanisms but have limited distribution upon direct intratumoral (i.t.) injection. Collagen bundles in the extracellular matrix (ECM) play an impo...

Descripción completa

Detalles Bibliográficos
Autores principales: Thaci, Bart, Ulasov, Ilya V., Ahmed, Atique U., Ferguson, Sherise D., Han, Yu, Lesniak, Maciej S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443547/
https://www.ncbi.nlm.nih.gov/pubmed/22673390
http://dx.doi.org/10.1038/gt.2012.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443547/
https://www.ncbi.nlm.nih.gov/pubmed/22673390
http://dx.doi.org/10.1038/gt.2012.42

Ejemplares similares