Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism

microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially co...

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Detalles Bibliográficos
Autores principales: Mandelbaum, Amitai D., Melkman-Zehavi, Tal, Oren, Roni, Kredo-Russo, Sharon, Nir, Tomer, Dor, Yuval, Hornstein, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443614/
https://www.ncbi.nlm.nih.gov/pubmed/22991506
http://dx.doi.org/10.1155/2012/470302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443614/
https://www.ncbi.nlm.nih.gov/pubmed/22991506
http://dx.doi.org/10.1155/2012/470302

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