Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms

Hydroxynitrile lyases (HNLs) catalyze the cleavage of cyanohydrins to yield hydrocyanic acid (HCN) and the respective carbonyl compound and are key enzymes in the process of cyanogenesis in plants. In organic syntheses, HNLs are used as biocatalysts for the formation of enantiopure cyanohydrins. We...

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Detalles Bibliográficos
Autores principales: Andexer, Jennifer N, Staunig, Nicole, Eggert, Thorsten, Kratky, Christoph, Pohl, Martina, Gruber, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444685/
https://www.ncbi.nlm.nih.gov/pubmed/22851196
http://dx.doi.org/10.1002/cbic.201200239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444685/
https://www.ncbi.nlm.nih.gov/pubmed/22851196
http://dx.doi.org/10.1002/cbic.201200239

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