Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene

Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic fun...

Descripción completa

Detalles Bibliográficos
Autores principales: Tirakarn, Srisuda, Riangrungroj, Pinpunya, Kongsaeree, Palangpon, Imwong, Mallika, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444756/
https://www.ncbi.nlm.nih.gov/pubmed/22234170
http://dx.doi.org/10.1016/j.parint.2011.12.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444756/
https://www.ncbi.nlm.nih.gov/pubmed/22234170
http://dx.doi.org/10.1016/j.parint.2011.12.004

Ejemplares similares