Cargando…

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene

Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic fun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tirakarn, Srisuda, Riangrungroj, Pinpunya, Kongsaeree, Palangpon, Imwong, Mallika, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444756/ https://www.ncbi.nlm.nih.gov/pubmed/22234170 http://dx.doi.org/10.1016/j.parint.2011.12.004

Ejemplares similares

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening
por: Somsak, Voravuth, et al.
Publicado: (2011)

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase
por: Songsungthong, Warangkhana, et al.
Publicado: (2021)

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
por: Pornthanakasem, Wichai, et al.
Publicado: (2012)

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
por: Begley, Darren W., et al.
Publicado: (2011)

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
por: Chaianantakul, Natpasit, et al.
Publicado: (2013)

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model
por: Tipsuwan, Wachiraporn, et al.
Publicado: (2011)

Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay
por: Sopitthummakhun, Kittipat, et al.
Publicado: (2012)

Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase
por: Songsungthong, Warangkhana, et al.
Publicado: (2019)

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes
por: Sienkiewicz, Natasha, et al.
Publicado: (2008)

Phosphorylation of Thymidylate Synthase and Dihydrofolate Reductase in Cancer Cells and the Effect of CK2α Silencing
por: Wińska, Patrycja, et al.
Publicado: (2023)

The bifunctional dihydrofolate reductase thymidylate synthase of Tetrahymena thermophila provides a tool for molecular and biotechnology applications
por: Herrmann, Lutz, et al.
Publicado: (2006)

Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases
por: Shamshad, Hina, et al.
Publicado: (2022)

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
por: Herrera-Acevedo, Chonny, et al.
Publicado: (2023)

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance
por: Tarnchompoo, Bongkoch, et al.
Publicado: (2018)

Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum
por: Auliff, Alyson M., et al.
Publicado: (2012)

Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment
por: Lee, Won-Ja, et al.
Publicado: (2010)

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
por: Choowongkomon, Kiattawee, et al.
Publicado: (2010)

Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi
por: Teixeira, Bárbara Velame Ferreira, et al.
Publicado: (2019)

Limited Polymorphism in the Dihydrofolate Reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand
por: Sangsri, Raweewan, et al.
Publicado: (2023)

An Innovative Strategy for Dual Inhibitor Design and Its Application in Dual Inhibition of Human Thymidylate Synthase and Dihydrofolate Reductase Enzymes
por: Arooj, Mahreen, et al.
Publicado: (2013)

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase
por: Gibson, Marc W., et al.
Publicado: (2016)

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine‐2,4‐diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase
por: Somandi, Khonzisizwe, et al.
Publicado: (2022)

Putative type 1 thymidylate synthase and dihydrofolate reductase as signature genes of a novel bastille-like group of phages in the subfamily Spounavirinae
por: Asare, Paul Tetteh, et al.
Publicado: (2015)

Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A
por: Vadloori, Bharadwaja, et al.
Publicado: (2018)

Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase
por: Duff, Michael R., et al.
Publicado: (2015)

BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms
por: Riangrungroj, Pinpunya, et al.
Publicado: (2019)

Disparate selection of mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium ovale curtisi and P. o. wallikeri in Africa
por: Chen, Jing, et al.
Publicado: (2022)

Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer
por: Li, Tao, et al.
Publicado: (2020)

Crystal structure of 1-(2,4-dihydroxy-6-methylphenyl)ethanone
por: Prabpai, Samran, et al.
Publicado: (2015)

Combined effects of double mutations on catalytic activity and structural stability contribute to clinical manifestations of glucose-6-phosphate dehydrogenase deficiency
por: Pakparnich, Phonchanan, et al.
Publicado: (2021)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
por: Penhallurick, Ryan W., et al.
Publicado: (2021)

Crystal structure of 4,6-diamino-2,2-dimethyl-3-[3-(2,4,5-trichlorophenoxy)propoxy]-2,3-dihydro-1,3,5-triazin-1-ium chloride methanol monosolvate
por: Khongsuk, Pattarapol, et al.
Publicado: (2015)

Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure
por: Sudsumrit, Sirapapha, et al.
Publicado: (2022)

Minimization of dynamic effects in the evolution of dihydrofolate reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2016)

Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
por: Asuncion Valenzuela, Malyn M, et al.
Publicado: (2015)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
por: Crabtree, Mark J., et al.
Publicado: (2011)

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
por: Sánchez-del-Campo, Luís, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_3mm02od8ldt5mjt0agjs25mai9