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Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation
The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest from the spindle. Here, we show that dynein light...
Autores principales: | Dunsch, Anja K., Hammond, Dean, Lloyd, Jennifer, Schermelleh, Lothar, Gruneberg, Ulrike, Barr, Francis A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444778/ https://www.ncbi.nlm.nih.gov/pubmed/22965910 http://dx.doi.org/10.1083/jcb.201202112 |
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