Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

BACKGROUND: TAK733 is a novel allosteric, non-ATP-binding, inhibitor of the BRAF substrates MEK-1/2. METHODS: The growth inhibitory effects of TAK733 were assessed in a panel of 27 cutaneous and five uveal melanoma cell lines genotyped for driver oncogenic mutations. Flow cytometry, Western blots an...

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Detalles Bibliográficos
Autores principales: von Euw, Erika, Atefi, Mohammad, Attar, Narsis, Chu, Connie, Zachariah, Sybil, Burgess, Barry L, Mok, Stephen, Ng, Charles, Wong, Deborah JL, Chmielowski, Bartosz, Lichter, David I, Koya, Richard C, McCannel, Tara A, Izmailova, Elena, Ribas, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444881/
https://www.ncbi.nlm.nih.gov/pubmed/22515704
http://dx.doi.org/10.1186/1476-4598-11-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444881/
https://www.ncbi.nlm.nih.gov/pubmed/22515704
http://dx.doi.org/10.1186/1476-4598-11-22

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