A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication

HIV-1 integrase (IN) is an important target for contemporary antiretroviral drug design research. Historically, efforts at inactivating the enzyme have focused upon blocking its active site. However, it has become apparent that new classes of allosteric inhibitors will be necessary to advance the an...

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Detalles Bibliográficos
Autores principales: Serrao, Erik, Thys, Wannes, Demeulemeester, Jonas, Al-Mawsawi, Laith Q., Christ, Frauke, Debyser, Zeger, Neamati, Nouri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445459/
https://www.ncbi.nlm.nih.gov/pubmed/23028829
http://dx.doi.org/10.1371/journal.pone.0045177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445459/
https://www.ncbi.nlm.nih.gov/pubmed/23028829
http://dx.doi.org/10.1371/journal.pone.0045177

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