Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines

In order to develop targeted strategies for combating drug resistance it is essential to understand it’s basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes,...

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Autores principales: Moitra, Karobi, Im, Kate, Limpert, Katy, Borsa, Alexander, Sawitzke, Julie, Robey, Rob, Yuhki, Naoya, Savan, Ram, Huang, Da Wei, Lempicki, Richard A., Bates, Susan, Dean, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445463/
https://www.ncbi.nlm.nih.gov/pubmed/23028896
http://dx.doi.org/10.1371/journal.pone.0045268
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author Moitra, Karobi
Im, Kate
Limpert, Katy
Borsa, Alexander
Sawitzke, Julie
Robey, Rob
Yuhki, Naoya
Savan, Ram
Huang, Da Wei
Lempicki, Richard A.
Bates, Susan
Dean, Michael
author_facet Moitra, Karobi
Im, Kate
Limpert, Katy
Borsa, Alexander
Sawitzke, Julie
Robey, Rob
Yuhki, Naoya
Savan, Ram
Huang, Da Wei
Lempicki, Richard A.
Bates, Susan
Dean, Michael
author_sort Moitra, Karobi
collection PubMed
description In order to develop targeted strategies for combating drug resistance it is essential to understand it’s basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.
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spelling pubmed-34454632012-10-01 Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines Moitra, Karobi Im, Kate Limpert, Katy Borsa, Alexander Sawitzke, Julie Robey, Rob Yuhki, Naoya Savan, Ram Huang, Da Wei Lempicki, Richard A. Bates, Susan Dean, Michael PLoS One Research Article In order to develop targeted strategies for combating drug resistance it is essential to understand it’s basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes. Public Library of Science 2012-09-18 /pmc/articles/PMC3445463/ /pubmed/23028896 http://dx.doi.org/10.1371/journal.pone.0045268 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Moitra, Karobi
Im, Kate
Limpert, Katy
Borsa, Alexander
Sawitzke, Julie
Robey, Rob
Yuhki, Naoya
Savan, Ram
Huang, Da Wei
Lempicki, Richard A.
Bates, Susan
Dean, Michael
Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
title Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
title_full Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
title_fullStr Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
title_full_unstemmed Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
title_short Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
title_sort differential gene and microrna expression between etoposide resistant and etoposide sensitive mcf7 breast cancer cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445463/
https://www.ncbi.nlm.nih.gov/pubmed/23028896
http://dx.doi.org/10.1371/journal.pone.0045268
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