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Distinct Licensing of IL-18 and IL-1β Secretion in Response to NLRP3 Inflammasome Activation
Inflammasome activation permits processing of interleukins (IL)-1β and 18 and elicits cell death (pyroptosis). Whether these responses are independently licensed or are “hard-wired” consequences of caspase-1 (casp1) activity has not been clear. Here, we show that that each of these responses is inde...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445464/ https://www.ncbi.nlm.nih.gov/pubmed/23028835 http://dx.doi.org/10.1371/journal.pone.0045186 |