A Conserved Motif in the ITK PH-Domain Is Required for Phosphoinositide Binding and TCR Signaling but Dispensable for Adaptor Protein Interactions

Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to the plasma membrane and its co-localization with th...

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Detalles Bibliográficos
Autores principales: Hirve, Nupura, Levytskyy, Roman M., Rigaud, Stephanie, Guimond, David M., Zal, Tomasz, Sauer, Karsten, Tsoukas, Constantine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445557/
https://www.ncbi.nlm.nih.gov/pubmed/23028816
http://dx.doi.org/10.1371/journal.pone.0045158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445557/
https://www.ncbi.nlm.nih.gov/pubmed/23028816
http://dx.doi.org/10.1371/journal.pone.0045158

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