Cargando…

NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses

RIG-I-like receptors (RLR) are intracellular sensors utilized by nearly all cell types for recognition of viral RNA, initiation of antiviral defense, and induction of type I interferons (IFN). TBK1 is a critical kinase implicated in RLR-dependent IFN transcription. Posttranslational modification of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lingyan, Li, Shitao, Dorf, Martin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445589/ https://www.ncbi.nlm.nih.gov/pubmed/23028469 http://dx.doi.org/10.1371/journal.pone.0043756

Ejemplares similares

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration
por: Jiang, Yuchuan, et al.
Publicado: (2021)

NEMO oligomerization and its ubiquitin-binding properties
por: Ivins, Frank J., et al.
Publicado: (2009)

TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes
por: Möser, Christine V., et al.
Publicado: (2015)

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation
por: Hu, Yi Wei, et al.
Publicado: (2018)

Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
por: Sui, Hongyan, et al.
Publicado: (2022)

Cleavage of TANK-Binding Kinase 1 by HIV-1 Protease Triggers Viral Innate Immune Evasion
por: Jeremiah, Sundararaj Stanleyraj, et al.
Publicado: (2021)

BACH1 Expression Is Promoted by Tank Binding Kinase 1 (TBK1) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin
por: Liu, Liang, et al.
Publicado: (2022)

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
por: Fu, Bishi, et al.
Publicado: (2015)

Silence of TANK-binding kinase 1 (TBK1) regulates extracellular matrix degradation of chondrocyte in osteoarthritis by janus kinase (JAK)-signal transducer of activators of transcription (STAT) signaling
por: Sun, Peng, et al.
Publicado: (2022)

TRAF5-mediated Tax ubiquitination modulates IKK phosphorylation but not binding to NEMO
por: Bonnet, Amandine, et al.
Publicado: (2014)

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
por: Fang, Run, et al.
Publicado: (2017)

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity
por: Louis, Cynthia, et al.
Publicado: (2018)

Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis
por: Said Halidi, Keïs Nabhane, et al.
Publicado: (2019)

Comparative In Silico Analysis and Functional Characterization of TANK-Binding Kinase 1–Binding Protein 1
por: Sawal, Humaira Aziz, et al.
Publicado: (2023)

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
por: Soulat, Didier, et al.
Publicado: (2008)

TBK1 Mediates Innate Antiviral Immune Response against Duck Enteritis Virus
por: Wang, Dongfang, et al.
Publicado: (2022)

Cyclic stretch regulates immune responses via tank‐binding kinase 1 expression in macrophages
por: Nakagawa, Anna, et al.
Publicado: (2022)

The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt
por: Tooley, Aaron Seth, et al.
Publicado: (2021)

GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation
por: Liu, Qianjin, et al.
Publicado: (2021)

SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15
por: Li, Lei, et al.
Publicado: (2022)

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis
por: Pillai, Smitha, et al.
Publicado: (2015)

Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling
por: You, Hongjuan, et al.
Publicado: (2019)

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
por: Li, Shang-Ze, et al.
Publicado: (2019)

Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
por: Tang, Jie-lin, et al.
Publicado: (2020)

Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN
por: Loevenich, Simon, et al.
Publicado: (2021)

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
por: Saha, Bhaskar, et al.
Publicado: (2023)

Angiogenin Reduces Immune Inflammation via Inhibition of TANK-Binding Kinase 1 Expression in Human Corneal Fibroblast Cells
por: Lee, Seung Hoon, et al.
Publicado: (2014)

The IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface
por: Barczewski, Adam H., et al.
Publicado: (2019)

Modelling of C-terminal tail of human STING and its interaction with tank-binding kinase 1
por: ATA OUDA AL-MASRI, Rahaf, et al.
Publicado: (2021)

TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1()()
por: Zotti, Tiziana, et al.
Publicado: (2014)

Commentary: Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity
por: Freischmidt, Axel, et al.
Publicado: (2020)

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
por: Ding, Chunyong, et al.
Publicado: (2020)

ZMPSTE24 defends against influenza and other pathogenic viruses
por: Fu, Bishi, et al.
Publicado: (2017)

Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production
por: Lv, Fangqiao, et al.
Publicado: (2021)

Knockdown of TANK-Binding Kinase 1 Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular-Targeted Drugs
por: Du, Fengxia, et al.
Publicado: (2022)

Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain
por: Rahighi, Simin, et al.
Publicado: (2022)

Hepatocyte nuclear factor 1A suppresses innate immune response by inducing degradation of TBK1 to inhibit steatohepatitis
por: He, Jinyong, et al.
Publicado: (2022)

Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
por: Huh, Jin Young, et al.
Publicado: (2021)

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
por: Zhu, Lele, et al.
Publicado: (2018)

RNF144B inhibits LPS‐induced inflammatory responses via binding TBK1
por: Zhang, Zhen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3027g9dpbrhpnl9nh2951uqtbo