Probing the Dynamics of Doxorubicin-DNA Intercalation during the Initial Activation of Apoptosis by Fluorescence Lifetime Imaging Microscopy (FLIM)

Doxorubicin is a potent anthracycline antibiotic, commonly used to treat a wide range of cancers. Although postulated to intercalate between DNA bases, many of the details of doxorubicin’s mechanism of action remain unclear. In this work, we demonstrate the ability of fluorescence lifetime imaging m...

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Detalles Bibliográficos
Autores principales: Chen, Nai-Tzu, Wu, Chia-Yan, Chung, Chao-Yu, Hwu, Yeukuang, Cheng, Shih-Hsun, Mou, Chung-Yuan, Lo, Leu-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445590/
https://www.ncbi.nlm.nih.gov/pubmed/23028696
http://dx.doi.org/10.1371/journal.pone.0044947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445590/
https://www.ncbi.nlm.nih.gov/pubmed/23028696
http://dx.doi.org/10.1371/journal.pone.0044947

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