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What inference for two-stage phase II trials?
BACKGROUND: Simon’s two-stage designs are widely used for cancer phase II trials. These methods rely on statistical testing and thus allow controlling the type I and II error rates, while accounting for the interim analysis. Estimation after such trials is however not straightforward, and several di...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445829/ https://www.ncbi.nlm.nih.gov/pubmed/22867439 http://dx.doi.org/10.1186/1471-2288-12-117 |