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Leishmania promastigotes: building a safe niche within macrophages
Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumul...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445913/ https://www.ncbi.nlm.nih.gov/pubmed/23050244 http://dx.doi.org/10.3389/fcimb.2012.00121 |
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author | Moradin, Neda Descoteaux, Albert |
author_facet | Moradin, Neda Descoteaux, Albert |
author_sort | Moradin, Neda |
collection | PubMed |
description | Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole. |
format | Online Article Text |
id | pubmed-3445913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-34459132012-10-04 Leishmania promastigotes: building a safe niche within macrophages Moradin, Neda Descoteaux, Albert Front Cell Infect Microbiol Microbiology Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole. Frontiers Media S.A. 2012-09-19 /pmc/articles/PMC3445913/ /pubmed/23050244 http://dx.doi.org/10.3389/fcimb.2012.00121 Text en Copyright © 2012 Moradin and Descoteaux. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Microbiology Moradin, Neda Descoteaux, Albert Leishmania promastigotes: building a safe niche within macrophages |
title | Leishmania promastigotes: building a safe niche within macrophages |
title_full | Leishmania promastigotes: building a safe niche within macrophages |
title_fullStr | Leishmania promastigotes: building a safe niche within macrophages |
title_full_unstemmed | Leishmania promastigotes: building a safe niche within macrophages |
title_short | Leishmania promastigotes: building a safe niche within macrophages |
title_sort | leishmania promastigotes: building a safe niche within macrophages |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445913/ https://www.ncbi.nlm.nih.gov/pubmed/23050244 http://dx.doi.org/10.3389/fcimb.2012.00121 |
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