Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification

In this paper we present a mathematical analysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligand to target, we give a qualitative characterisation of ligand versus time graphs for different dosing regimes and derive accurate analytic approximations of...

Descripción completa

Detalles Bibliográficos
Autores principales: Peletier, Lambertus A., Gabrielsson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446204/
https://www.ncbi.nlm.nih.gov/pubmed/22851162
http://dx.doi.org/10.1007/s10928-012-9260-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446204/
https://www.ncbi.nlm.nih.gov/pubmed/22851162
http://dx.doi.org/10.1007/s10928-012-9260-6

Ejemplares similares