Cargando…
Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification
In this paper we present a mathematical analysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligand to target, we give a qualitative characterisation of ligand versus time graphs for different dosing regimes and derive accurate analytic approximations of...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446204/ https://www.ncbi.nlm.nih.gov/pubmed/22851162 http://dx.doi.org/10.1007/s10928-012-9260-6 |