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LARGE enzyme activity deciphered: a new therapeutic target for muscular dystrophies
A significant proportion of severe, inherited congenital muscular dystrophies are due to aberrant glycosylation of the extracellular matrix receptor α-dystroglycan and a consequent lack of ligand-binding activity. A key member of this glycosylation pathway is the LARGE protein, which was originally...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446273/ https://www.ncbi.nlm.nih.gov/pubmed/22458537 http://dx.doi.org/10.1186/gm322 |