Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

BACKGROUND: Nonsense-mediated mRNA decay (NMD) affects the outcome of alternative splicing by degrading mRNA isoforms with premature termination codons. Splicing regulators constitute important NMD targets; however, the extent to which loss of NMD causes extensive deregulation of alternative splicin...

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Detalles Bibliográficos
Autores principales: Weischenfeldt, Joachim, Waage, Johannes, Tian, Geng, Zhao, Jing, Damgaard, Inge, Jakobsen, Janus Schou, Kristiansen, Karsten, Krogh, Anders, Wang, Jun, Porse, Bo T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446288/
https://www.ncbi.nlm.nih.gov/pubmed/22624609
http://dx.doi.org/10.1186/gb-2012-13-5-r35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446288/
https://www.ncbi.nlm.nih.gov/pubmed/22624609
http://dx.doi.org/10.1186/gb-2012-13-5-r35

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