γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells

INTRODUCTION: Inappropriate Notch signaling, downstream of γ-secretase activity, is understood to have tumor-promoting function and to be associated with poor outcome in cancer, of the breast in particular. The molecular basis of antitumoral effects of its inhibitors, however, remains poorly charact...

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Detalles Bibliográficos
Autores principales: Séveno, Céline, Loussouarn, Delphine, Bréchet, Sophie, Campone, Mario, Juin, Philippe, Barillé-Nion, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446359/
https://www.ncbi.nlm.nih.gov/pubmed/22703841
http://dx.doi.org/10.1186/bcr3214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446359/
https://www.ncbi.nlm.nih.gov/pubmed/22703841
http://dx.doi.org/10.1186/bcr3214

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