BRCA1 as tumor suppressor: lord without its RING?

BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long s...

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Detalles Bibliográficos
Autores principales: Elia, Andrew EH, Elledge, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446363/
https://www.ncbi.nlm.nih.gov/pubmed/22494569
http://dx.doi.org/10.1186/bcr3118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446363/
https://www.ncbi.nlm.nih.gov/pubmed/22494569
http://dx.doi.org/10.1186/bcr3118

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