BRCA1 as tumor suppressor: lord without its RING?

BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long s...

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Detalles Bibliográficos
Autores principales: Elia, Andrew EH, Elledge, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446363/
https://www.ncbi.nlm.nih.gov/pubmed/22494569
http://dx.doi.org/10.1186/bcr3118
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author Elia, Andrew EH
Elledge, Stephen J
author_facet Elia, Andrew EH
Elledge, Stephen J
author_sort Elia, Andrew EH
collection PubMed
description BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using genetically engineered mouse models, two recent studies shed light on this age-old hypothesis.
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spelling pubmed-34463632012-10-10 BRCA1 as tumor suppressor: lord without its RING? Elia, Andrew EH Elledge, Stephen J Breast Cancer Res Viewpoint BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using genetically engineered mouse models, two recent studies shed light on this age-old hypothesis. BioMed Central 2012 2012-04-10 /pmc/articles/PMC3446363/ /pubmed/22494569 http://dx.doi.org/10.1186/bcr3118 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Viewpoint
Elia, Andrew EH
Elledge, Stephen J
BRCA1 as tumor suppressor: lord without its RING?
title BRCA1 as tumor suppressor: lord without its RING?
title_full BRCA1 as tumor suppressor: lord without its RING?
title_fullStr BRCA1 as tumor suppressor: lord without its RING?
title_full_unstemmed BRCA1 as tumor suppressor: lord without its RING?
title_short BRCA1 as tumor suppressor: lord without its RING?
title_sort brca1 as tumor suppressor: lord without its ring?
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446363/
https://www.ncbi.nlm.nih.gov/pubmed/22494569
http://dx.doi.org/10.1186/bcr3118
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AT elledgestephenj brca1astumorsuppressorlordwithoutitsring

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