BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control

BRCA1 is a tumor suppressor gene known to be implicated in the development of a subset of breast and ovarian cancers. The tumor suppressor properties of BRCA1 are generally thought to be linked to the gene's critical roles in the network of DNA damage response. In a recent report, BRCA1-mediate...

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Detalles Bibliográficos
Autores principales: Stefansson, Olafur Andri, Esteller, Manel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446364/
https://www.ncbi.nlm.nih.gov/pubmed/22423979
http://dx.doi.org/10.1186/bcr3119
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author Stefansson, Olafur Andri
Esteller, Manel
author_facet Stefansson, Olafur Andri
Esteller, Manel
author_sort Stefansson, Olafur Andri
collection PubMed
description BRCA1 is a tumor suppressor gene known to be implicated in the development of a subset of breast and ovarian cancers. The tumor suppressor properties of BRCA1 are generally thought to be linked to the gene's critical roles in the network of DNA damage response. In a recent report, BRCA1-mediated epigenetic repression at the promoter region of miRNA-155 was identified as a novel mechanism by which BRCA1 carries out its tumor suppressor functions.
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spelling pubmed-34463642012-09-20 BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control Stefansson, Olafur Andri Esteller, Manel Breast Cancer Res Viewpoint BRCA1 is a tumor suppressor gene known to be implicated in the development of a subset of breast and ovarian cancers. The tumor suppressor properties of BRCA1 are generally thought to be linked to the gene's critical roles in the network of DNA damage response. In a recent report, BRCA1-mediated epigenetic repression at the promoter region of miRNA-155 was identified as a novel mechanism by which BRCA1 carries out its tumor suppressor functions. BioMed Central 2012 2012-03-16 /pmc/articles/PMC3446364/ /pubmed/22423979 http://dx.doi.org/10.1186/bcr3119 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Viewpoint
Stefansson, Olafur Andri
Esteller, Manel
BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control
title BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control
title_full BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control
title_fullStr BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control
title_full_unstemmed BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control
title_short BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control
title_sort brca1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomirs under control
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446364/
https://www.ncbi.nlm.nih.gov/pubmed/22423979
http://dx.doi.org/10.1186/bcr3119
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