Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER(+ )breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim

INTRODUCTION: In this pre-clinical in vitro study conducted in estrogen receptor positive (ER+) breast cancer cells, we have characterized the effects of insulin-like growth factor I (IGF-1) on the cytostatic and cytotoxic action of antiestrogen treatment when used as a single agent or in combinatio...

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Detalles Bibliográficos
Autores principales: Periyasamy-Thandavan, Sudharsan, Takhar, Suchreet, Singer, Adam, Dohn, Michael Robert, Jackson, William Hutch, Welborn, April Eve, LeRoith, Derek, Marrero, Mario, Thangaraju, Muthusamy, Huang, Shuang, Schoenlein, Patricia Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446386/
https://www.ncbi.nlm.nih.gov/pubmed/22429491
http://dx.doi.org/10.1186/bcr3153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446386/
https://www.ncbi.nlm.nih.gov/pubmed/22429491
http://dx.doi.org/10.1186/bcr3153

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