Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer

INTRODUCTION: Perp is a transcriptional target of both p53 during DNA damage-induced apoptosis and p63 during stratified epithelial development. Perp-/- mice exhibit postnatal lethality associated with dramatic blistering of the epidermis and oral mucosa, reflecting a critical role in desmosome-medi...

Descripción completa

Detalles Bibliográficos
Autores principales: Dusek, Rachel L, Bascom, Jamie L, Vogel, Hannes, Baron, Sylvain, Borowsky, Alexander D, Bissell, Mina J, Attardi, Laura D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446400/
https://www.ncbi.nlm.nih.gov/pubmed/22515648
http://dx.doi.org/10.1186/bcr3171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446400/
https://www.ncbi.nlm.nih.gov/pubmed/22515648
http://dx.doi.org/10.1186/bcr3171

Ejemplares similares