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Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer

INTRODUCTION: Perp is a transcriptional target of both p53 during DNA damage-induced apoptosis and p63 during stratified epithelial development. Perp-/- mice exhibit postnatal lethality associated with dramatic blistering of the epidermis and oral mucosa, reflecting a critical role in desmosome-medi...

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Detalles Bibliográficos
Autores principales:	Dusek, Rachel L, Bascom, Jamie L, Vogel, Hannes, Baron, Sylvain, Borowsky, Alexander D, Bissell, Mina J, Attardi, Laura D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446400/ https://www.ncbi.nlm.nih.gov/pubmed/22515648 http://dx.doi.org/10.1186/bcr3171

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