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Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis
INTRODUCTION: Rheumatoid arthritis (RA) is associated with hypogalactosylation of immunoglobulin G (IgG). We examined whether a proxy measure for galactosylation of IgG N-glycans could predict response to therapy or was differentially affected by methotrexate (MTX) or TNF blockade. METHODS: Using a...
Autores principales: | Ercan, Altan, Cui, Jing, Hazen, Melissa M, Batliwalla, Franak, Royle, Louise, Rudd, Pauline M, Coblyn, Jonathan S, Shadick, Nancy, Weinblatt, Michael E, Gregersen, Peter, Lee, David M, Nigrovic, Peter A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446410/ https://www.ncbi.nlm.nih.gov/pubmed/22390545 http://dx.doi.org/10.1186/ar3756 |
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