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Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration
INTRODUCTION: The longitudinal degradation mechanism of extracellular matrix (ECM) in the interbertebral disc remains unclear. Our objective was to elucidate catabolic and anabolic gene expression profiles and their balances in intervertebral disc degeneration using a static compression model. METHO...
Autores principales: | Yurube, Takashi, Takada, Toru, Suzuki, Teppei, Kakutani, Kenichiro, Maeno, Koichiro, Doita, Minoru, Kurosaka, Masahiro, Nishida, Kotaro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446417/ https://www.ncbi.nlm.nih.gov/pubmed/22394620 http://dx.doi.org/10.1186/ar3764 |
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