Cargando…

The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells

INTRODUCTION: The goals of this study were to examine the oxemic regulation of Wnt signaling to explore whether Wnt signaling accelerates the age-related degeneration of nucleus pulposus cells, and if so, to define the mechanism underlying this effect. We investigated the expression of Klotho, a new...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hiyama, Akihiko, Arai, Fumiyuki, Sakai, Daisuke, Yokoyama, Katsuya, Mochida, Joji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446482/ https://www.ncbi.nlm.nih.gov/pubmed/22551380 http://dx.doi.org/10.1186/ar3830

Ejemplares similares

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2013)

Effect of Cryopreservation on Canine and Human Activated Nucleus Pulposus Cells: A Feasibility Study for Cell Therapy of the Intervertebral Disc
por: Tanaka, Masahiro, et al.
Publicado: (2013)

C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells
por: Yokoyama, Katsuya, et al.
Publicado: (2013)

CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt–β-catenin signaling in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2018)

Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGFβ-1 in cultured rat nucleus pulposus cells
por: Nakai, Tomoko, et al.
Publicado: (2008)

Cell Signaling Pathways Related to Pain Receptors in the Degenerated Disk
por: Hiyama, Akihiko, et al.
Publicado: (2013)

Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro
por: Nukaga, Tadashi, et al.
Publicado: (2019)

BMP-2 and TGF-β Stimulate Expression of β1,3-Glucuronosyl Transferase 1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP, and Sp1: Role of MAPKs
por: Hiyama, Akihiko, et al.
Publicado: (2010)

Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
por: Prud’homme, Gérald J., et al.
Publicado: (2022)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease
por: Maltese, Giuseppe, et al.
Publicado: (2012)

Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review
por: Volleman, Tibo Nico Emmie, et al.
Publicado: (2020)

Transcriptome and alternative splicing analysis of nucleus pulposus cells in response to high oxygen tension: Involvement of high oxygen tension in the pathogenesis of intervertebral disc degeneration
por: Feng, Chencheng, et al.
Publicado: (2018)

The Association of Obesity and the Antiaging Humoral Factor Klotho in Middle-Aged and Older Adults
por: Orces, Carlos H.
Publicado: (2022)

Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Lin, Yi, et al.
Publicado: (2015)

Reduced Levels of the Antiaging Hormone Klotho are Associated With Increased Aortic Stiffness in Diabetic Kidney Disease
por: Fountoulakis, Nikolaos, et al.
Publicado: (2023)

Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against Intervertebral Disc Degeneration
por: Xu, Zeng, et al.
Publicado: (2021)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health
por: Suyama, Kaori, et al.
Publicado: (2016)

Antiaging gene Klotho regulates epithelial-mesenchymal transition and increases sensitivity to pemetrexed by inducing lipocalin-2 expression
por: Takegahara, Kyoshiro, et al.
Publicado: (2021)

Bag-1 Protects Nucleus Pulposus Cells from Oxidative Stress by Interacting with HSP70
por: Suyama, Kaori, et al.
Publicado: (2023)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

In-Vivo Nucleus Pulposus-Specific Regulation of Adult Murine Intervertebral Disc Degeneration via Wnt/Beta-Catenin Signaling
por: Holguin, Nilsson, et al.
Publicado: (2018)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
por: Sakai, Daisuke, et al.
Publicado: (2018)

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2016)

The enigma that is the nucleus pulposus cell: the search goes on
por: Erwin, W Mark
Publicado: (2010)

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
por: Krouwels, Anita, et al.
Publicado: (2020)

Cell sources proposed for nucleus pulposus regeneration
por: Williams, Rebecca J., et al.
Publicado: (2021)

Alterations of bovine nucleus pulposus cells with aging
por: Molinos, Maria, et al.
Publicado: (2023)

Effects of Oxygen Concentration and Culture Time on Porcine Nucleus Pulposus Cell Metabolism: An in vitro Study
por: Jaworski, Lukas M., et al.
Publicado: (2019)

p-Coumaric acid suppresses reactive oxygen species-induced senescence in nucleus pulposus cells
por: Sheng, Kunkun, et al.
Publicado: (2022)

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration
por: Richardson, Stephen M., et al.
Publicado: (2017)

Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells
por: Munesada, Daiki, et al.
Publicado: (2023)

Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2019)

Antiaging Factor Klotho Retards the Progress of Intervertebral Disc Degeneration through the Toll-Like Receptor 4-NF-κB Pathway
por: Bi, Fangfang, et al.
Publicado: (2020)

Analysis of the association between serum antiaging humoral factor klotho and cardiovascular disease potential risk factor apolipoprotein B in general population
por: Chen, Zhiyi, et al.
Publicado: (2023)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions
por: Sinkemani, Arjun, et al.
Publicado: (2020)

Osseous erosion by herniated nucleus pulposus mimicking intraspinal tumor: a case report
por: Yoshioka, Shinji, et al.
Publicado: (2010)

The antiaging role of oxytocin
por: Benameur, Tarek, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gi0h62metc1nltecbn0qh5r3h1