Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase

[Image: see text] Incorporation of divalent metal ions into an active site is a fundamental catalytic tool used by diverse enzymes. Divalent cations are used by protein kinases to both stabilize ATP binding and accelerate chemistry. Kinetic analysis establishes that Cyclin-dependent kinase 2 (CDK2)...

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Detalles Bibliográficos
Autores principales: Jacobsen, Douglas M., Bao, Zhao-Qin, O’Brien, Patrick, Brooks, Charles L., Young, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446636/
https://www.ncbi.nlm.nih.gov/pubmed/22891849
http://dx.doi.org/10.1021/ja304419t

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446636/
https://www.ncbi.nlm.nih.gov/pubmed/22891849
http://dx.doi.org/10.1021/ja304419t

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