Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors

Edema Factor (EF) is a component of Bacillus anthracis toxin essential for virulence. Its adenylyl cyclase activity is induced by complexation with the ubiquitous eukaryotic cellular protein, calmodulin (CaM). EF and its complexes with CaM, nucleotides and/or ions, have been extensively characterize...

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Detalles Bibliográficos
Autores principales: Laine, Élodie, Martínez, Leandro, Ladant, Daniel, Malliavin, Thérèse, Blondel, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446745/
https://www.ncbi.nlm.nih.gov/pubmed/23012649
http://dx.doi.org/10.3390/toxins4080580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446745/
https://www.ncbi.nlm.nih.gov/pubmed/23012649
http://dx.doi.org/10.3390/toxins4080580

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