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Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors
Edema Factor (EF) is a component of Bacillus anthracis toxin essential for virulence. Its adenylyl cyclase activity is induced by complexation with the ubiquitous eukaryotic cellular protein, calmodulin (CaM). EF and its complexes with CaM, nucleotides and/or ions, have been extensively characterize...
Autores principales: | Laine, Élodie, Martínez, Leandro, Ladant, Daniel, Malliavin, Thérèse, Blondel, Arnaud |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446745/ https://www.ncbi.nlm.nih.gov/pubmed/23012649 http://dx.doi.org/10.3390/toxins4080580 |
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