7α-Hydroxy-β-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular Bax/Bcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK1/2 Activation

In continuation of our interest towards the elucidation of apoptotic pathways of cytotoxic phytocompounds, we have embarked upon a study on the anticancer effects of 7α-hydroxy-β-sitosterol (CT1), a rare natural phytosterol oxide isolated from Chisocheton tomentosus. CT1 was found to be cytotoxic on...

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Detalles Bibliográficos
Autores principales: Tasyriq, Mohammad, Najmuldeen, Ibrahim A., In, Lionel L. A., Mohamad, Khalit, Awang, Khalijah, Hasima, Noor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446807/
https://www.ncbi.nlm.nih.gov/pubmed/22997533
http://dx.doi.org/10.1155/2012/765316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446807/
https://www.ncbi.nlm.nih.gov/pubmed/22997533
http://dx.doi.org/10.1155/2012/765316

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