Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

Drug-induced liver injury (DILI) in humans is difficult to predict using classical in vitro cytotoxicity screening and regulatory animal studies. This explains why numerous compounds are stopped during clinical trials or withdrawn from the market due to hepatotoxicity. Thus, it is important to impro...

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Detalles Bibliográficos
Autores principales: Porceddu, Mathieu, Buron, Nelly, Roussel, Célestin, Labbe, Gilles, Fromenty, Bernard, Borgne-Sanchez, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446843/
https://www.ncbi.nlm.nih.gov/pubmed/22987451
http://dx.doi.org/10.1093/toxsci/kfs197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446843/
https://www.ncbi.nlm.nih.gov/pubmed/22987451
http://dx.doi.org/10.1093/toxsci/kfs197

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