PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity

Hepatocyte growth factor (HGF) and its receptor (c-Met) are associated with cancer cell motility and invasiveness. p21-activated kinase 4 (PAK4), a potential therapeutic target, is recruited to and activated by c-Met. In response, PAK4 phosphorylates LIM kinase 1 (LIMK1) in an HGF-dependent manner i...

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Detalles Bibliográficos
Autores principales: Whale, Andrew D., Dart, Anna, Holt, Mark, Jones, Gareth E., Wells, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446866/
https://www.ncbi.nlm.nih.gov/pubmed/22689056
http://dx.doi.org/10.1038/onc.2012.233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446866/
https://www.ncbi.nlm.nih.gov/pubmed/22689056
http://dx.doi.org/10.1038/onc.2012.233

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