Valproic Acid Downregulates RBP4 and Elicits Hypervitaminosis A-Teratogenesis—A Kinetic Analysis on Retinol/Retinoic Acid Homeostatic System

BACKGROUND: Valproic acid (VPA) is an antiepileptic and anti-migraine prophylactic drug. VPA exhibits two severe side effects, namely acute liver toxicity and teratogenicity. These side effects are usually seen at the genetic and somatic levels. The cited action mechanisms involve inhibition of hist...

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Detalles Bibliográficos
Autores principales: Chuang, Chao-Ming, Chang, Chi-Huang, Wang, Hui-Er, Chen, Kuan-Chou, Peng, Chiung-Chi, Hsieh, Chiu-Lan, Peng, Robert Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446952/
https://www.ncbi.nlm.nih.gov/pubmed/23028466
http://dx.doi.org/10.1371/journal.pone.0043692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446952/
https://www.ncbi.nlm.nih.gov/pubmed/23028466
http://dx.doi.org/10.1371/journal.pone.0043692

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