Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

Sirtuins are protein deacylases regulating metabolism and aging processes, and the seven human isoforms are considered attractive therapeutic targets. Sirtuins transfer acyl groups from lysine sidechains to ADP-ribose, formed from the cosubstrate NAD(+) by release of nicotinamide, which in turn is a...

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Detalles Bibliográficos
Autores principales: Fischer, Frank, Gertz, Melanie, Suenkel, Benjamin, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Steegborn, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446968/
https://www.ncbi.nlm.nih.gov/pubmed/23028781
http://dx.doi.org/10.1371/journal.pone.0045098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446968/
https://www.ncbi.nlm.nih.gov/pubmed/23028781
http://dx.doi.org/10.1371/journal.pone.0045098

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