The structure of the ternary Eg5–ADP–ispinesib complex

The human kinesin Eg5 is responsible for bipolar spindle formation during early mitosis. Inhibition of Eg5 triggers the formation of monoastral spindles, leading to mitotic arrest that eventually causes apoptosis. There is increasing evidence that Eg5 constitutes a potential drug target for the deve...

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Detalles Bibliográficos
Autores principales: Talapatra, S. K., Schüttelkopf, A. W., Kozielski, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447400/
https://www.ncbi.nlm.nih.gov/pubmed/22993085
http://dx.doi.org/10.1107/S0907444912027965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447400/
https://www.ncbi.nlm.nih.gov/pubmed/22993085
http://dx.doi.org/10.1107/S0907444912027965

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