Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives

A new series of pyrazolo[3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde [1-(4-chlorophenyl)-3-methyl-1H-pyrazol...

Descripción completa

Detalles Bibliográficos
Autores principales: Kandeel, Manal M., Mohamed, Lamia W., Abd El Hamid, Mohammed K., Negmeldin, Ahmed T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447607/
https://www.ncbi.nlm.nih.gov/pubmed/23008804
http://dx.doi.org/10.3797/scipharm.1204-23
_version_ 1782244124382986240
author Kandeel, Manal M.
Mohamed, Lamia W.
Abd El Hamid, Mohammed K.
Negmeldin, Ahmed T.
author_facet Kandeel, Manal M.
Mohamed, Lamia W.
Abd El Hamid, Mohammed K.
Negmeldin, Ahmed T.
author_sort Kandeel, Manal M.
collection PubMed
description A new series of pyrazolo[3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde [1-(4-chlorophenyl)-3-methyl-1H-pyrazolo-[3,4-d]pyrimidin-4-yl]hydrazone (VIIa) was found to be the most effective among the other derivatives, showing IC50 values of 0.326 to 4.31 μM on 57 different cell lines.
format Online
Article
Text
id pubmed-3447607
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Österreichische Apotheker-Verlagsgesellschaft
record_format MEDLINE/PubMed
spelling pubmed-34476072012-09-24 Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives Kandeel, Manal M. Mohamed, Lamia W. Abd El Hamid, Mohammed K. Negmeldin, Ahmed T. Sci Pharm Research Article A new series of pyrazolo[3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde [1-(4-chlorophenyl)-3-methyl-1H-pyrazolo-[3,4-d]pyrimidin-4-yl]hydrazone (VIIa) was found to be the most effective among the other derivatives, showing IC50 values of 0.326 to 4.31 μM on 57 different cell lines. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-06-25 /pmc/articles/PMC3447607/ /pubmed/23008804 http://dx.doi.org/10.3797/scipharm.1204-23 Text en © Kandeel et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kandeel, Manal M.
Mohamed, Lamia W.
Abd El Hamid, Mohammed K.
Negmeldin, Ahmed T.
Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
title Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
title_full Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
title_fullStr Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
title_full_unstemmed Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
title_short Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
title_sort design, synthesis, and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidine derivatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447607/
https://www.ncbi.nlm.nih.gov/pubmed/23008804
http://dx.doi.org/10.3797/scipharm.1204-23
work_keys_str_mv AT kandeelmanalm designsynthesisandantitumorevaluationofnovelpyrazolo34dpyrimidinederivatives
AT mohamedlamiaw designsynthesisandantitumorevaluationofnovelpyrazolo34dpyrimidinederivatives
AT abdelhamidmohammedk designsynthesisandantitumorevaluationofnovelpyrazolo34dpyrimidinederivatives
AT negmeldinahmedt designsynthesisandantitumorevaluationofnovelpyrazolo34dpyrimidinederivatives

Ejemplares similares