IFN-γ and TNF-α Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling. While the T-helper 1 (Th1) cytokine interferon-gamma (IFN-γ) is well characterized as immune-modulatory and anti-fibrotic cytokine, the...

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Detalles Bibliográficos
Autores principales: Laug, Roderich, Fehrholz, Markus, Schütze, Norbert, Kramer, Boris W., Krump-Konvalinkova, Vera, Speer, Christian P., Kunzmann, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447888/
https://www.ncbi.nlm.nih.gov/pubmed/23029004
http://dx.doi.org/10.1371/journal.pone.0045430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447888/
https://www.ncbi.nlm.nih.gov/pubmed/23029004
http://dx.doi.org/10.1371/journal.pone.0045430

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