Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1α With CREB-Binding Protein

The activation of glucose-6-phosphatase (G6Pase), a key enzyme of endogenous glucose production, is correlated with type 2 diabetes. Type 2 diabetes is characterized by sustained hyperglycemia leading to glucotoxicity. We investigated whether glucotoxicity mechanisms control the expression of the G6...

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Detalles Bibliográficos
Autores principales: Gautier-Stein, Amandine, Soty, Maud, Chilloux, Julien, Zitoun, Carine, Rajas, Fabienne, Mithieux, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447892/
https://www.ncbi.nlm.nih.gov/pubmed/22787137
http://dx.doi.org/10.2337/db11-0986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447892/
https://www.ncbi.nlm.nih.gov/pubmed/22787137
http://dx.doi.org/10.2337/db11-0986

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