Catalase Prevents Maternal Diabetes–Induced Perinatal Programming via the Nrf2–HO-1 Defense System

We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring of nondiabetic and diabetic dams from two transgenic (Tg) lines (Hoxb7-gre...

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Detalles Bibliográficos
Autores principales: Chang, Shiao-Ying, Chen, Yun-Wen, Zhao, Xin-Ping, Chenier, Isabelle, Tran, Stella, Sauvé, Alexandre, Ingelfinger, Julie R., Zhang, Shao-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447903/
https://www.ncbi.nlm.nih.gov/pubmed/22733796
http://dx.doi.org/10.2337/db12-0248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447903/
https://www.ncbi.nlm.nih.gov/pubmed/22733796
http://dx.doi.org/10.2337/db12-0248

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